منابع مشابه
Taxol induces caspase-10-dependent apoptosis.
Taxol (paclitaxel) is known to inhibit cell growth and trigger significant apoptosis in various cancer cells. Although taxol induces apoptosis of cancer cells, its exact mechanism of action is not yet known. In this study we investigated death receptors, FAS-associated death domain protein (FADD), the activation of caspases-10 and -8 as well as the downstream caspases, and reactive oxygen speci...
متن کاملActivation of p34cdc2 coincident with taxol-induced apoptosis.
Toxicity elicited by the antitumor compound taxol has been linked to irreversible tubulin polymerization, cell cycle block at mitosis, and cell death from apoptosis. We have used pulsed drug exposure of synchronized populations to identify two points, one in transition from G0 to G1 and the other at G2/M of cell cycle, that are most sensitive to taxol-induced cell killing. By analyzing these le...
متن کاملColonic perforation secondary to taxol therapy: an unusual presentation.
Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com Our patient, however, was not neutropenic or feverish on the day of admission, since she received the cytostatics just one day prior to admission. Usually this complication is seen 7–14 days after a chemotherapy course [3, 4]. So this sequela in our patient is rather unusual and unexpecte...
متن کاملTaxol produced from endophytic fungi induces apoptosis in human breast, cervical and ovarian cancer cells.
Currently, taxol is mainly extracted from the bark of yews; however, this method can not meet its increasing demand on the market because yews grow very slowly and are a rare and endangered species belonging to first- level conservation plants. Recently, increasing efforts have been made to develop alternative means of taxol production; microbe fermentation would be a very promising method to i...
متن کاملpRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol.
PURPOSE In addition to their original function as cell cycle regulators, retinoblastoma (Rb) family members were recently reported to modulate the sensitivity of cancer cells to chemotherapeutic agents. The purpose of this study is to investigate the possible role of pRb2/p130 in the sensitivity of ovarian cancer to camptothecin, doxorubicin, and taxol. EXPERIMENTAL DESIGN pRb2/p130 was overe...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2002
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.54